Breakthrough Awards 2022 Winners Announced (2)

A2022 Breakthrough Awards in Life Sciences, Fundamental Physics and Mathematics Winners Announced

$ 15.75 million in prizes for discoveries leading to vaccines for Covid-19, treatments for neurological diseases, quantum clocks of unprecedented precision and other important discoveries

Breakthrough Award in Life Sciences awarded to Shankar Balasubramanian, David Klenerman and Pascal Mayer ; Katalin Karikó y Drew Weissman; and Jeffery W. Kelly

Breakthrough Prize in Mathematics awarded to Takuro Mochizuki

Breakthrough Prize in Fundamental Physics awarded to Hidetoshi Katori and Jun Ye

Six New Horizons Awards Awarded for Career Achievements in Physics and Mathematics

Three Maryam Mirzakhani New Frontiers Awards given to female mathematicians for their early career achievements

Live and TV awards ceremony postponed until 2022 due to pandemic

SAN FRANCISCO, September 9, 2021 / PRNewswire / – The Breakthrough Prize Foundation and its Founding Sponsors –Sergey Brin, Priscilla Chan and Mark Zuckerberg, Yuri y Julia Milner, and Anne Wojcicki– today announced the winners of the 10th Annual Breakthrough Awards, awarding a total of $ 15.75 million to a esteemed group of laureates and early career scientists.

The Breakthrough Award recognizes groundbreaking discoveries in Fundamental Physics, Life Sciences, and Mathematics. Each of the top five Breakthrough Awards, the world’s largest science award, is endowed with $ 3 million. It is traditionally held during a live televised awards ceremony honoring the laureates, but this year it is postponed until 2022 due to the pandemic.

The scientific and medical response to Covid-19 has been unprecedented, and two of this year’s awards are for breakthroughs that have played an important role in that response. The innovators vaccines developed by Pfizer / BioNTech and Moderna that have been shown to be effective against the virus are based on decades of work by Katalin Karikó and Drew Weissman. Convinced of the promise of mRNA therapies Despite widespread skepticism, they created technology that is not only vital in the fight against coronavirus today, but holds great promise for future vaccines and treatments for a wide range of diseases, including HIV, cancer, and disease. autoimmune and genetic.

Meanwhile, the almost immediate identification and characterization of the virus, the rapid development of vaccines, and the real-time monitoring of new genetic variants would have been impossible without the technologies of next generation sequencing invented by Shankar Balasubramanian, David Klenerman y Pascal Mayer. Before his inventions, resequencing an entire human genome could take many months and cost millions of dollars; today, it can be done in one day at a cost of about $ 600. This has been a revolution in biology, allowing the revelation of unsuspected genetic diversity with important implications from microbiome and cell biology to ecology, forensic medicine and personalized medicine.

While Covid is a crisis, the fight against neurodegenerative diseases is an ever-present emergency. Jeffery W. Kelly has made a difference in the lives of people who suffer amyloid diseases that affect the heart and nervous system. He demonstrated the mechanism by which a protein, transthyretin, unravels and clumps together into clumps that kill cells, tissues, and ultimately patients. He then devised a molecular approach to stabilize the protein, and after synthesizing 1,000 candidate molecules, one of the engineered molecules had the right structure to achieve this stabilization. He then helped develop it into an effective drug, called tafamidis, which considerably slows the progression of these diseases. In the process, he provided evidence for the notion that protein aggregation causes neurodegeneration, which has relevance for other neurodegenerative diseases, including Alzheimer’s disease.

Since the dawn of science, improvements in precision measurement have led to discoveries. Hidetoshi Katori and Jun YeWorking independently, they have improved the precision of time measurement by 3 orders of magnitude. His tabletop-scale techniques for using lasers to trap, cool, and probe atoms, produce quantum clocks so precise they would lose less than a second if they worked for 15 billion years. These optical lattice clocks they have potential technological applications, from quantum computing to the use of Einstein’s relativity effects for seismology; and in fundamental research they can be used to test theories such as relativity, as well as to search for gravitational waves and new physics such as dark matter.

While experimenters investigate the physical world with increasing precision, mathematicians explore the boundaries of mind-boggling abstract spaces. Takuro Mochizuki works in the interface of the algebraic geometry -where the solutions to the systems of equations appear as geometric objects- and the differential geometry -where the smooth surfaces unfold in multiple and complex dimensions-. Mochizuki overcame immense technical and conceptual challenges to push the limits of knowledge into a new terrain, broadening the understanding of objects called holonomic D modules to include varieties with singularities, points at which the equations studied stop making sense. In the process, he has laid a complete foundation for the field, solving all the long-lasting basic guesses.

In addition to the main prizes, six AwardsNew Horizons, endowed with $ 100,000 each, between 13 scientists and novice mathematicians who have already had a substantial impact in their fields. In addition, three AwardsMaryam Mirzakhani New Frontiers to women mathematicians in their beginnings.

Including the New Horizons and New Frontiers awards for early career achievements, this year a total of $ 15.75 million is awarded, bringing the total amount awarded to scientists and mathematicians to $ 276.5 million. pioneers throughout the Prize’s decade of existence.

Full mentions are below.

2022 Breakthrough Awards in Life Sciences

Jeffery W. KellyScripps Research Institute

For elucidating the molecular bases of neurodegenerative diseases and cardiac transthyretin, and for developing tafamidis, a drug that slows its progression.

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Katalin KarikóBioNTech and University of Pennsylvania

Drew WeissmanUniversity of Pennsylvania

By engineered modified RNA technology that enabled the rapid development of effective COVID-19 vaccines.

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Shankar BalasubramanianUniversity of Cambridge

David KlenermanUniversity of Cambridge

Pascal MayerAlphanosos

For the development of a robust and affordable method for determining DNA sequences on a large scale, which has transformed the practice of science and medicine.

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Breakthrough Award 2022 in Fundamental Physics

Hidetoshi KatoriUniversity of Tokyo and RIKEN

Jun YeNational Institute of Standards and Technology y University of Colorado

For his outstanding contribution to the invention and development of the optical network clock, which allows precision testing of the fundamental laws of nature.

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Breakthrough Prize 2022 in Mathematics

Takuro MochizukiKyoto University

For a monumental work that has meant a great advance in our understanding of the theory of beams with plane connections on algebraic varieties, including the case of irregular singularities.

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New Horizons 2022 Award in Physics

Suchitra SebastianUniversity of Cambridge

For high-precision electronic and magnetic measurements that have profoundly changed our understanding of high-temperature superconductors and unconventional insulators.

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Alessandra CorsiTexas Tech University

Gregg HallinanCalifornia Institute of Technology

Mansi Manoj KasliwalCalifornia Institute of Technology

Raffaella Margutti University of California, Berkeley

For his leadership in establishing the basis for electromagnetic observations of gravitational wave sources, and for his leadership in extracting rich information from the first observed collision of two neutron stars.

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Dominic ElseHarvard University

Vedika KhemaniStanford University

Haruki WatanabeThe University of Tokyo

Norman Y. YaoUniversity of California, Berkeley

For his pioneering theoretical work in formulating new phases of unbalanced quantum matter, including time crystals.

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New Horizons 2022 Award in Mathematics

Aaron BrownNorthwestern University

Sebastian Hurtado SalazarUniversity of Chicago

For his contribution to the proof of the Zimmer conjecture.

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Jack ThorneUniversity of Cambridge

For his transformative contributions in various areas of algebraic number theory, and in particular for proof, in collaboration with James Newton, of the automorphy of all symmetric powers of a new holomorphic modular form.

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Jacob TsimermanUniversity of Toronto

For his outstanding work in analytical number theory and arithmetic geometry, including advances on the André-Oort and Griffiths conjectures.

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Premio Maryam Mirzakhani New Frontiers 2022

Sarah PeluseInstitute for Advanced Study and Princeton University (PhD Stanford University 2019)

For his contributions to arithmetic combinatorics and analytic number theory, especially with regard to polynomial patterns in dense sets.

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Hong Wang |University of California, Los Angeles (PhD MIT 2019)

For advances in the Constraint Conjecture, the Local Smoothing Conjecture, and related problems.

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Yilin WangWITH (PhD ETH Zurich 2019)

For innovative and powerful work on Loewner’s energy of flat curves.

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About the Breakthrough AwardFor the tenth year, the Breakthrough Award, recognized as the “Oscars of Science”, recognizes the best scientists in the world. Each award is $ 3 million and is presented in the fields of Life Sciences, Fundamental Physics (one per year), and Mathematics (one per year). Additionally, up to three New Horizons Awards in Physics, up to three New Horizons in Mathematics, and up to three Maryam Mirzakhani New Frontiers Awards are given to new researchers each year. The awardees attend a gala ceremony designed to celebrate their achievements and inspire the next generation of scientists. What part of the program of ceremonies, they also participate in a program of lectures and talks.

The Breakthrough Awards were founded by Sergey Brin, Priscilla Chan and Mark Zuckerberg, Yuri y Julia Milner, and Anne Wojcicki. The Awards have been sponsored by personal foundations established by Sergey Brin, Priscilla Chan and Mark Zuckerberg, Ma Huateng, Jack Ma, Yuri y Julia Milner and Anne Wojcicki. Selection Committees comprised of previous Breakthrough Award recipients in each field select the winners. Information on the Breakthrough Prize is available at breakthroughprize.org.

Article: Soure